the less u know the better by Nadia Morozewicz

How to read RANKL/RANK control Breastcancer1 mutation-driven mammary tumors: Breast Cancer is one of the most common cancers in human and will, on average, affect up to one in eight women in their lifetime in the United States and Europe. Imagine Google Earth to zoom far into your body, this is the right view to look at this series. Cells understand RANKL in various ways. In the bone they interpret this signal by chewing up old bits of skeleton and replacing them with fresh cells. This releases a cloud of calcium that the blood washes away. In a woman's breast, RANKL makes immature cells into adults and presses them into the construction of a milk factory. A shipment of calcium is due soon, to be converted into milk and delivered through the mammary gland. So RANKL tells bone cells to tear tissue down, and the breast to construct something new — not a contradiction, but a collaboration coordinated by hormones and the multiple meanings of RANKL. RANKL can cause problems in elderly people who lack fresh cells to replace bone; this can lead to osteoporosis. When cells in the breast or lung have been damaged by cancer, hearing RANKL may make things worse. What can you do? Make cells forget the word? That would be especially hard in females because their snowflake hormones keep urging cells to say it. Why not make it unreadable by changing its shape and taste? Josef Penninger and his team managed to make it unreadable. Based on their genetic findings, a drug called Denosumab has been developed to treat osteoporosis and protect bones from breaking in cancer. At the same time, the drug might also be the key for a preventative breast cancer treatment. Initial results have been positive and clinical trials will be starting soon.This series is a visualisation of that almost magical drug Denosumab which could help healing some breast cancer patients. Nadia built a world in a microscopic view on our inner body. ISBN: 978-3-11-063048-0

Institute of molecular biotechnology